What can your pathology report tell you about TNBC? Among people with this TNBC, 35% have the BRCA1 genetic variant and 8% the BRCA2 variant, whereas less than 10% of all newly diagnosed breast cancer patients carry these genetic variants 10.ĭid you know? The NHS offers genetic testing for BRCA1 and BRCA2 gene variants to women under 50 with triple negative breast cancer, including those with no family history of breast or ovarian cancer 11.įor more information about familiar risk and breast cancer genetic mutations, head to our previous blog on BRCA. ![]() BRCA stands for breast cancer susceptibility gene. The most common genes that have been found to impact the person’s chances to develop breast cancer are BRCA1 and BRCA2 genes. Triple negative breast cancer is often genetically determined and appears to run in families 9. TNBC represents approximately 10-15% of all diagnosed breast cancers 1, 2, with over 8,000 cases diagnosed every year in the UK 3. This type of breast cancer seems to be more common in African 4, 5 and Latina women 6, as well as in women under 40 7, 8. ![]() Here we are going to explain the characteristics of triple negative disease, the treatments that are commonly used, as well as newly approved treatments and potential therapies currently undergoing clinical trials. And it clearly seems to me we are improving outcomes and cure rates.” – Dr Peter Schmid, Chair in cancer medicine at Barts Cancer Institute, Queen Mary University of London. We are clearly improving the treatments in early TNBC. “From my perspective, this means there is a huge amount of hope. However, recent developments in research have allowed for a better understanding of TNBC and opened doors for new treatment options. This has meant TNBC has had limited treatment options, namely surgery and chemotherapy. Most recent treatments have been developed for breast cancer with these receptors. So what is it not? TNBC means the growth of the cancer does not involve oestrogen, progesterone (hormones often associated with breast cancer) receptors and HER2 receptors. As summed up by Dr Isakoff, TNBC has been defined by not what it is, but what it isn’t. ![]() It’s time to focus on Triple Negative Breast Cancer (TNBC). “I want to be defined by what I am, not by what I am not” – Dr Steven Isakoff (Breast Oncologist) on Triple Negative Breast Cancer
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